Marcus Boehme

APC Microbiome Ireland

I hold a life-long passion for understanding the benefits of a healthy diet. Growing up on my family’s fruit and vegetable farm, I was first introduced to the idea that a healthy diet drives a healthy lifestyle. In fact, it is increasingly recognized that healthy nutrition is a key to mental health. Numerous studies have shown that the trillions of bacteria residing in the gut can influence brain function and brain health with being diet to be one of the major and easy accessible factors in modulating the composition of the gut microbiota. Fascinated by the various impact of the gut microbiome on host health, I joined APC. My research seeks to investigate how diet shapes brain health across lifespan through the gut microbiota. I’m particularly interested in the mechanisms by which the gut microbiota drives healthy aging. Follow me on Twitter @BoehmeMarcus and find out more about the impact of the gut microbiota on health, development and aging.
In my research I’m focussing a lot on the immune cells in the brain, the microglia, in order to assess if manipulations to the microbiome shapes the behavior of them and their activation grade. I attached you an immunohistochemistry picture – here you see microglia in the hippocampus of an aged mouse. Particularly the picture shows the dentate gyrus region of the hippocampus (the white packed areas which have a high density of neurons but no microglia), in the zone where new neurons are born (neurogenesis).